ISOLATED PERIORBITAL EDEMA ASSOCIATED WITH NAPROXEN: A CASE REPORT

Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs), resulting in urticaria and angioedema, is being observedwith increasing frequency partly due to the large size of the exposed (at risk) population. Prevalence rates range from 0.1–0.3%. Facial angioedema constitutes the most common form of clinical presentation, and one-third of the patients show amixed clinical pattern of cutaneous (urticaria and/or angioedema) and respiratory symptoms which include upper respiratorytract edema, rhinorrhea, cough, breathlessness and tearing. But to the best of our knowledge there is no isolated periorbitaledema reported to date due to naproxen in the literature. In this report, a 62-year-old woman who developed reversiblebilateral periorbital edema after naproxen ingestion was presented. The periorbital edema due to NSAIDs was discussed